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Receptor Family
Neurexins
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Summary

Neurexins are a family of cell adhesion receptors. They are characterized by the production of numerous alternatively spliced variants. Consequently there are thousands of distinct receptor isoforms (Missler et al. 1998). The majority are alpha-neurexins whereas a much smaller number are beta-neurexins. The alpha-neurexins contain EGF-like and laminin G domains, whereas the beta-neurexins lack EGF-like sequences and contain fewer laminin G domains. For each of the four human genes the mode of alternative splicing is what defines if the protein product is alpha or beta (Ichtchenko et al. 1995).
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