Receptor Family
Cytokine1R    IL2RG(Cytokine Type 1 receptors)
(Summary from Cytokine Type 1 receptors)

Ligand-induced homo- or hetero-oligomerization of receptors This family, also known as the haematopoietic receptor family, is characterized by a common extracellular domain with two barrels each composed of seven beta strands. There is a single transmembrane domain followed by a cytoplasmic region that shows little similarity between family members except for two motifs: box 1 and box 2 This large family is divided into four classes on the basis of the subunits - , , , and gp130 - that are involved in the formation of different receptor complexes The haematopoietic class includes -subunit homodimeric receptors, among which are the growth hormone receptor and the prolactin receptor. IL-3 class shares an -subunit and a -subunit, and its members include IL-3, IL-5, and GM-CSF receptors. IL-2 class shares the -subunit and includes some heterotrimeric members with - - and -subunits (IL-2 and IL-15 receptors) and some heterodimeric members with only - and -subunits (IL-7, IL-9, and IL-4 receptors). The IL-6 class members all share the gp subunit, IL-6 and IL-11 receptors being dimeric, whereas LIF, CNTF, OSM, and CT-1 receptors are trimeric. In most cases, ligands induce heteromerization of several receptor subunits that are characteristic for each subgroup, but in a few cases - for example, the growth hormone receptor -receptors are activated by ligand-induced homodimerization. Regardless of the mechanism, receptor oligomerization induces activation of the JAK/STAT pathway A prominent feature of this superfamily is the production, by alternative splicing or proteolysis, of truncated receptors, which serve as binding proteins, whether secreted or membrane-anchored. Receptor redundancy and ligand promiscuity. Type I cytokine receptors are present in many tissues and induce diverse target cell-specific effects. This ligand-receptor system shows a high degree of redundancy and promiscuity, such that several ligands may induce the same response(s) through a given receptor, or one ligand may activate several receptors. Receptors of this superfamily are important for haematopoiesis, immune responses, inflammation, bone modeling, neural development, and reproduction. Analyses of the gene structures of the IFN- -receptor and the type 1 cytokine receptors indicate that they have a common origin with immunoglobulins A JAK/STAT-activating receptor remotely related to gp130131 was found in D. melanogaster but more evidence is needed before concluding whether this receptor family exists in nonvertebrates.
Relevant reviews and publications:
1662392, 9692895, 10681548, 11312115,7621100, 1370833
no tree for this subfamily