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Receptor Family
Receptor Tyrosine Kinases (RTK)   
MAIN | RECEPTORS | INTERACTIONS | New! DNA MICROARRY DATA
Summary

This large and diverse family of receptors exemplifies several general principles of receptor-ligand and receptor-receptor interactions. All members of the large receptor tyrosine kinase (RTK) family have a similar cytoplasmic catalytic domain that is activated by conformational changes upon ligand engagement whereas members within each subfamily have homologous extracellular domains. RTKs may have been vital in establishing the first metazoans - no RTKs are found in yeasts or plants. In mammals, multicellular organization is highly dependent on the proper functioning of RTKs as many RTKs become oncogenic when their activity is altered. Although up to 20 RTK classes were suggested, five major classes, each of which has several orthologs in C. elegans and D. melanogaster, will be considered here.
Relevant reviews and publications:
10966463, 2158859, 8398110
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