RANK, the receptor activator of NF-kappaB, and its ligand RANKL (initially termed TRANCE, also termed ODF and OPGL), are a TNF superfamily receptor-ligand pair that govern the development and function of osteoclasts, lymphoid tissue, and mammary epithelium (lam et al. 2001)
. Crystal structure of RANK ligand involved in bone metabolism.
(Ito & Hata 2004)