Synonyms:SAX3, C. ELEGANS, HOMOLOG OF, 1|DELETED IN U TWENTY TWENTY, DUTT1
links:Entrez Gene, Omim
Summary: (from NCBI-Entrez) ..[read more]Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The
Yuan et asl. (1999) demonstrated that the mouse SLIT1 protein can bind ROBO1, a transmembrane receptor implicated in axon guidance.Syndecan is a necessary component of Slit/Robo signaling and is required in the Slit target cells (Steigemann et al. 2004).
Brose K,et al. (Cell. 1999) characterized three mammalian Slit homologs and showed that the Drosophila Slit protein and at least one of the mammalian Slit proteins, Slit2, are proteolytically processed and show specific, high-affinity binding to Robo proteins (Robo1 and Robo2).Syndecan is a necessary component of Slit/Robo signaling and is required in the Slit target cells (Steigemann et al. 2004).