Summary: (from NCBI-Entrez) ..[read more]This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the be
Umbhauer M, et al. (EMBO J. 2000) studied the Frizzled/Wnt signaling pathway and found that Xfz3 activates this pathway in the absence of exogenous ligands, while Xfz4 and Xfz7 interact with Xwnt5A to activate this pathway.