Summary: (from NCBI-Entrez) ..[read more]This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, a
Mosley B,et al. (J Biol Chem. 1996) Cloned and characterized an alternative signaling subunit conferring OSM-specific receptor activation.The receptor for OSM is a dimmer of OSMR-beta and gp130. The combination of gp130-LIFR-alpha is also a receptor for human OSM (Wang et al. 2000).
IL-31 signals through a heterodimeric receptor which combines GPL (gp130-like receptor) and OSMR-beta (Dillon et al. 2004). This composit receptor uses the longest out of four splice variants of GPL (Drew et al. 2004).