Loughna S, Sato TN.(Mol Cell. 2001)
Phenotypes of the Ang-1, TIE2, and TIE1 single-knockout embryos have been previously described. However, none of them exhibit differences in the phenotypes between LHS and RHS vascular networks. While, when Ang-1−/− TIE1−/− Embryos Exhibit a Specific Absence of a Right-Hand Side Venous System but a Normal Left-Hand Side. Therefore, we reasoned that there may be cooperative interactions among the angiopoietins (i.e., ligands for TIE2) and TIE1, the orphan receptor.