Summary: (from NCBI-Entrez) ..[read more]This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In
The Laminin-1 trimer, composed of laminins alpha-1, beta-1, and gamma-1 subunits, was found to promote neurite outgrowth on rat dorsal root ganglionic neurons, expressing integrin-beta-8, through a specific interaction. The integrin alpha partner in the receptor heterodimer was not defined (Venstrom & Reichardt, 1995).
Fibronectin was found to induce neurite outgrowth in rat dorsal root ganglionic neurons, expressing integrin beta-8, through a specific binding. However, the inegrin alpha partner of integrin beta-8 was not defined (Vestrom & Reichardt, 1995).