Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity.
Schall TJ, et al. (Cell. 1990) cloned a human tumor necrosis factor (TNF) binding protein, which, transfected into human embryonic kidney cells specifically bind both 125I-labeled and biotinylated TNF-alpha.