Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member o
Receptor CSF2RA interacts with:
Receptor CSF2RB - CYTOKINE RECEPTOR COMMON BETA CHAIN PRECU ...andLigand CSF2 - GRANULOCYTE-MACROPHAGE COLONY-STIMULATING F ...[read more..]
DiPersio J,et al. (J Biol Chem, 1988) firstly reported the CSF receptor GM-CSFR.Heterodimeric cytokine receptors generally consist of a major cytokine-binding subunit and a signaling subunit. The latter can transduce signals by more than 1 cytokine, as exemplified by the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and IL-6 receptor systems (Rossjohn et al. 2000).