Summary: (from NCBI-Entrez) ..[read more] Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellula
Umbhauer M, et al. (EMBO J. 2000)studied the Frizzled/Wnt signaling pathway and found that Xfz3 activates this pathway in the absence of exogenous ligands, while Xfz4 and Xfz7 interact with Xwnt5A to activate this pathway.
Djiane A, et al. (Development, 2000)investigated the expression and functional analyses of frizzled 7 (Xfz7) during gastrulation in Xenopus and found that Xfz7 biochemically and functionally interacts with Xwnt11. And Xwnt 11 signals are medited via Xfz7.