TNFRSF10C - TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10C PRECURSORFamily:TNFNGF|TRAIL
Synonyms:T10C_HUMAN,(Decoy receptor 1) (DcR1) (Decoy TRAIL receptor without death domain) (TNF- related apoptosis-inducing ligand receptor 3) (TRAIL receptor-3) (TRAIL-R3)
links:Entrez Gene, Omim
Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.(MacFarlane et al. 1997).
Because of its lack of a death domain, TRAIL receptor-3 is not capable of inducing apoptosis and functions as a decoy receptor.