COL2A1 - COLLAGEN, TYPE II, ALPHA 1 (PRIMARY OSTEOARTHRITIS, SPONDYLOEPIPHYSEAL DYSPLASIA, CONGENITAL)Family:collagen
Synonyms:COLLAGEN, TYPE II|COLLAGEN OF CARTILAGE|CHONDROCALCIN, INCLUDED|VITREORETINOPATHY WITH PHALANGEAL EPIPHYSEAL DYSPLASIA, INCLUDED COL2A1
links:Entrez Gene, Omim
Summary: (from NCBI-Entrez) ..[read more]This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED cong
Chondrocyte adhesion on native collagen II was completely blocked by anti-beta 1; anti-alpha 2 reduced chondrocyte binding to collagen by only 40-50%; This led Durr et al. (1993) to suggest that alpha-2 beta-1-integrin may be involved in the assembly of a pericellular collagen matrix in vitro.