Summary: (from NCBI-Entrez) ..[read more]This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor
RANK, the receptor activator of NF-kappaB, and its ligand RANKL (initially termed TRANCE, also termed ODF and OPGL), are a TNF superfamily receptor-ligand pair that govern the development and function of osteoclasts, lymphoid tissue, and mammary epithelium (lam et al. 2001). Crystal structure of RANK ligand involved in bone metabolism.
(Ito & Hata 2004).
Osteoprotegerin (OPG; TNFRSF11B) also known as osteoclastogenesis inhibitory factor (OCIF), is a secreted member of the TNFR family. OPG is a decoy receptor of RANKL and inhibits osteoclast maturation (Ito et al. 2002).