Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are req
Yuan et asl. (1999) demonstrated that the mouse SLIT1 protein can bind ROBO1, a transmembrane receptor implicated in axon guidance.Syndecan is a necessary component of Slit/Robo signaling and is required in the Slit target cells (Steigemann et al. 2004).
Brose K,et al. (Cell. 1999) characterized three mammalian Slit homologs and showed that the Drosophila Slit protein and at least one of the mammalian Slit proteins, Slit2, are proteolytically processed and show specific, high-affinity binding to Robo proteins (Robo1 and Robo2).Syndecan is a necessary component of Slit/Robo signaling and is required in the Slit target cells (Steigemann et al. 2004).