Summary: (from NCBI-Entrez) ..[read more]This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocyt
PTGS2/COX2 is one of the rate-limiting synthases to convert arachidonic acid to prostaglandins, the ligands for prostaglandin receptors. Hirai H, et al. (J Exp Med. 2001) cloned a CRTH2 and found that CRTH2 serves as the novel receptor for PGD2.