Rajagopalan et al. (2004)
presented evidence that neogenin functions as a receptor for repulsive guidance molecule (RGM). Like Rgm, neogenin was expressed in a gradient across the embryonic chicken retina. The avoidance of Rgm by chicken temporal retinal axons was blocked by anti-neogenin antibody and the soluble neogenin ectodomain. Dorsal root ganglion axons were unresponsive to Rgm, but were converted to a responsive state by neogenin expression.