Synonyms:NEUROPEPTIDE Y RECEPTOR Y3, NPY3R|FUSIN|D2S201E|LEUKOCYTE-DERIVED SEVEN-TRANSMEMBRANE-DOMAIN RECEPTOR, LESTR|SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR, SPLEEN|HM89|LIPOPOLYSACCHARIDE-ASSOCIATED PROTEIN 3, LAP3|LPS-ASSOCIATED PROTEIN 3 CXCR4
links:Entrez Gene, Omim
Summary: (from NCBI-Entrez) ..[read more]This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in
Bleul CC, et al. (Nature, 1996) firstly demonstrated that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a receptor for LESTR, which we therefore designate CXC-chemokine receptor-4 (CXCR-4).
Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cellsBroxmeyer et al. 2003