Summary: (from NCBI-Entrez) ..[read more]ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte fu
Interplay between rolling and firm adhesion elucidated with a cell-free system engineered with two distinct receptor-ligand pairs.Eniola AO et al. . The interaction between integrin lymphocyte function-associated antigen-1 (LFA-1) and its ligand intercellular adhesion molecule-1 (ICAM-1) is critical in immunological and inflammatory reactions,The extracellular domains of LFA-1 are composed of the large and complex αL and β2 subunits (Song et al. 2005).
The extracellular domain of LFA-1 are composed of the large and complex integrin α-L and β2 subunits. Pig ICAM-2 expressed on stable transfectants supported firm adhesion of cells expressing human LFA-1 (Godwin et al. 2004).
ICAM-4 is a red cell intercellular adhesion molecule. Cell transfectants expressing various integrins were used to demonstrate that integrins alpha-L-beta-2, alpha-M-beta-2, and alpha-IIb-beta-3 bind specifically and dose dependently to the recombinant ICAM-4-Fc protein. Cell surface ICAM-4 interacts with the cell surface alpha-V-beta-3 integrin (Hermand et al. 2004).