Yao Z, et al. (Cytokine. 1997)
characterized the human interleukin (IL)-17 receptor.They found that mnoclonal antibodies (mAbs) generated against the hIL-17R were able to block the IL-17-induced production of cytokine from human foreskin fibroblast (HFF) cells. Binding studies suggest that recombinant hIL-17 binds to the hIL-17R with low affinity.