Expression and dynamic modulation of the human granulocyte colony-stimulating factor receptor (CD114) in immature and differentiated myeloid cells (Jilma et al. 2000)
.Mutational analysis of the G-CSFR indicated that the N-terminal region of its cytoplasmic domain is sufficient to transduce the proliferation signal into cells, while the C-terminal region plays an essential role in transducing the differentiation signal.
(Fukunaga et al. 1993)